SEVERE — -15 pts

Octinoxate (Octyl Methoxycinnamate)

Flags: S-R02

Also known as: Octyl methoxycinnamate, OMC, Ethylhexyl methoxycinnamate, Parsol MCX

Kids Sunscreen & Skincare

What it is

Octinoxate is a chemical UV filter that absorbs UVB radiation. It is one of the most commonly used sunscreen ingredients worldwide and is found in sunscreens, moisturizers, lip balms, and cosmetics with SPF claims.

SEVERE

Octinoxate is an endocrine disruptor with demonstrated estrogenic and thyroid-disrupting activity. It was banned in Hawaii alongside oxybenzone for coral reef damage. FDA's 2019 proposed rule requested additional safety data.

Why it matters

Endocrine disruption: estrogenic and thyroid-disrupting activity in animal and in vitro studies
Systemic absorption exceeding FDA threshold after normal use
Photoinstability: degrades in sunlight, reducing UV protection over time
Coral reef bleaching and marine ecosystem toxicity
Reproductive effects in animal studies at relevant exposure levels

The research

Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients

Matta MK, Zusterzeel R, Pilli NR, et al. JAMA, 2019. 321(21):2082-2091 PMID: 31058986 [Source]

"Octinoxate was among sunscreen ingredients exceeding the FDA systemic absorption threshold of 0.5 ng/mL"

Who should care most

Children with developing endocrine systems. Individuals applying sunscreen daily. Pregnant individuals (thyroid disruption concern).

How other countries handle it

Country	Status
United States	Permitted. FDA requested additional safety data (2019). Banned in Hawaii (effective 2021).
European Union	Permitted at max 10% concentration.
Canada	Permitted.
Australia	Permitted.

Sources

Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients. Matta MK, Zusterzeel R, Pilli NR, et al. JAMA, 2019. 321(21):2082-2091. PubMed 31058986

For informational purposes only. Not medical or dietary advice. Consult your pediatrician. Data current as of March 24, 2026.